Fig. 2

Effect of SF on onset and clinical symptoms of arthritis in CIA mice. a Flow chart of CIA model induction and treatment options. b Incidence of arthritis in each group (n = 5). c Arthritis scores of mice in each group (n = 5). d Hind paw swelling of mice in each group (n = 5). e Representative images of feet in each group after one-month administration (n = 5). f Body weight of mice in each group. Values are presented as means ± SEM. Two-way ANOVA and post hoc Dunnett’s test were performed between multiple groups. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with CIA vehicle group