Articles

The effects of bioactive components from the rhizome of Salvia miltiorrhiza (Danshen) on the characteristics of Alzheimer’s disease

Alzheimer’s disease (AD) is a common human neurodegenerative disease, which is characterized by the progressive loss of memory and the cognitive impairment. Since the etiology of AD is still unknown, it is ext...

Authors: Cheong-Meng Chong, Huanxing Su, Jin-Jian Lu and Yitao Wang

Metabolomics analysis of herb-partitioned moxibustion treatment on rats with diarrhea-predominant irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which is commonly treated with antidiarrhoeal, antispasmodics, serotonergic agents or laxative agents. These treatments provide ...

Authors: Xianwei Lin, Xia Liu, Jingjing Xu, Kian-Kai Cheng, Jianan Cao, Tao Liu, Qiong Liu, Huan Zhong, Guiping Shen, Jiyang Dong and Xiaorong Chang

Review of traditional uses, botany, chemistry, pharmacology, pharmacokinetics, and toxicology of Radix Cyathulae

Cyathulae Radix (CR), also known as “Chuanniux” is a well-known traditional Chinese herbal medicine that has been used in China for thousands of years. The present work reviewed advances in traditional uses, o...

Authors: Yongliang Huang, Shanshan Wang, Li Liu, Wei Peng, Jiaolong Wang, Ying Song, Qianghua Yuan, Xing Yuan and Chunjie Wu

Combination of 15 lipid metabolites and motilin to diagnose spleen-deficiency FD

This study aims to assess clinical characteristics in FD with spleen deficiency syndrome and metabolic perturbations involved in FD progress. We combined metabolic biomarkers and clinical features into a bette...

Authors: Jiaqi Zhang, Xue Wang, Xiaoshuang Shi, Jingyi Xie, Min Zhang, Jinxin Ma, Fengyun Wang and Xudong Tang

Brain connectomic associations with traditional Chinese medicine diagnostic classification of major depressive disorder: a diffusion tensor imaging study

Major depressive disorder (MDD) is highly heterogeneous in pathogenesis and manifestations. Further classification may help characterize its heterogeneity. We previously have shown differential metabolomic pro...

Authors: Lan-Ying Liu, Xiao-Pei Xu, Li-Yuan Luo, Chun-Qing Zhu, Ya-Ping Li, Pei-Rong Wang, Yuan-Yuan Zhang, Chun-Yu Yang, Hong-Tao Hou, Yu-Lin Cao, Gang Wang, Edward S. Hui and Zhang-Jin Zhang

A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense

The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this fam...

Authors: Cuicui Jia, Chi Gong, Hong Chen, Jing Pu, Dahong Li, Zhanlin Li and Huiming Hua

Fabrication of paper-based enzyme immobilized microarray by 3D-printing technique for screening α-glucosidase inhibitors in mulberry leaves and lotus leaves

The discovery of bioactive compounds in traditional Chinese medicine (TCM) has become an important field in TCM modernization. Ligand fishing is a suitable method for discovery of bioactive compounds in comple...

Authors: Shangxin Guo, Xiaotong Lin, Yi Wang and Xingchu Gong

Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology

Water extract (WAE) and ultrafine powder (UFP) are two types of commonly used supplements in preparing various pharmaceutical products and functional foods. However, the correlations of the chemical compositio...

Authors: Zhi Xin Li, Guan Ding Zhao, Wei Xiong, Ke Gang Linghu, Qiu Shuo Ma, Wai San Cheang, Hua Yu and Yitao Wang

Developing natural products as potential anti-biofilm agents

Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotic...

Authors: Lan Lu, Wei Hu, Zeru Tian, Dandan Yuan, Guojuan Yi, Yangyang Zhou, Qiang Cheng, Jie Zhu and Mingxing Li

Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells

Homeostasis is a crucial concept used to describe the condition of patients and the roles of herbs in traditional Chinese medicine. Qi-deficiency pattern is one of the conditions when loss of homeostasis and i...

Authors: Pin-Hao Ko, Chiung-Wei Huang, Hen-Hong Chang, Eric Y. Chuang, Mong-Hsun Tsai and Liang-Chuan Lai

Plastid genome and composition analysis of two medical ferns: Dryopteris crassirhizoma Nakai and Osmunda japonica Thunb.

Dryopteris crassirhizoma Nakai and Osmunda japonica Thunb. are ferns that are popularly used for medicine, as recorded by the Chinese pharmacopoeia, and are distributed in different regions of China. However, O. ...

Authors: Liang Xu, Yanping Xing, Bing Wang, Chunsheng Liu, Wenquan Wang and Tingguo Kang

Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine

Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown. As a systemic approach, metabolomics provides...

Authors: Lili Lin, Hua Yan, Jiabin Chen, Huihui Xie, Linxiu Peng, Tong Xie, Xia Zhao, Shouchuan Wang and Jinjun Shan

Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investig...

Authors: Zhu Wang, Jianhua Yin, Mingxing Li, Jing Shen, Zhangang Xiao, Yueshui Zhao, Chengliang Huang, Hanyu Zhang, Zhuo Zhang, Chi Hin Cho and Xu Wu

Rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of Fuzi-Lizhong pill based on high-throughput HPLC-Q-TOF/MS analysis

Fuzi-Lizhong pill (FZLZP), which was first recorded in the Classic–“Taiping Huimin Heji Ju Fang” of the Song Dynasty, has been widely used to treat gastrointestinal disease in clinic for thousands of years in ...

Authors: Zhen Zhang, Maoyuan Jiang, Xinyi Wei, Jinfeng Shi, Zhao Geng, Shasha Yang, Chaomei Fu and Li Guo

High content screening for drug discovery from traditional Chinese medicine

Traditional Chinese medicine (TCM) represents the crystallization of Chinese wisdom and civilization. It has been valued as the renewable source for the discovery of novel drugs, owing to its long-term proved ...

Authors: Jing Wang, Ming-Yue Wu, Jie-Qiong Tan, Min Li and Jia-Hong Lu

A new GIS model for ecologically suitable distributions of medicinal plants

The endangered rate of medicinal plant exceeds that of endangered plant species. However, blindly introducing medicinal plants in regions without comprehensively considering the involved environmental factors ...

Authors: Jie Wu, Xiwen Li, Linfang Huang, Xiangxiao Meng, Haoyu Hu, Lu Luo and Shilin Chen

Baduanjin exerts anti-diabetic and anti-depression effects by regulating the expression of mRNA, lncRNA, and circRNA

Baduanjin, a traditional Chinese exercise therapy, has been widely used in China to treat type 2 diabetes (T2DM) with depression (DD). However, the underlying mechanism of Baduanjin in anti-DD is unclear. This...

Authors: Tian An, Zhong-Chen He, Xin-Qing Zhang, Jun Li, Ai-Ling Chen, Fang Tan, Hong-Dong Chen, Bo-Han Lv, Juan Lian, Si-Hua Gao and Guang-Jian Jiang

Chinese herb pair Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma suppresses LPS-induced inflammatory response through inhibiting MAPK and NF-κB pathway

The combination of Radix Paeoniae Alba (RPA) and Rhizoma Atractylodis Macrocephalae (RAM) has long been used as a classic herb pair for the treatment of gynecologic and gastrointestinal diseases, but the under...

Authors: Yangyang Zhou, Hongxun Tao, Anqi Wang, Zhangfeng Zhong, Xu Wu, Mei Wang, Zhaoxiang Bian, Shengpeng Wang and Yitao Wang

Differential proteomics for studying action mechanisms of traditional Chinese medicines

Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes ...

Authors: Yi-Yao Yang, Feng-Qing Yang and Jian-Li Gao

Systems biology approaches in the study of Chinese herbal formulae

Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biologic...

Authors: Fei-Fei Cai, Wen-Jun Zhou, Rong Wu and Shi-Bing Su

An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model

The incidence and mortality of cancer metastasis is high worldwide. Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments. Howe...

Authors: Grace Gar-Lee Yue, Julia Kin-Ming Lee, Ben Chung-Lap Chan, Hin-Fai Kwok, Sandy Wan-Heng Hoi, Daniel Man-Yuen Sze, Kwok-Pui Fung, Ping-Chung Leung and Clara Bik-San Lau

Gut microbiota was modulated by moxibustion stimulation in rats with irritable bowel syndrome

The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of mox...

Authors: Xiaomei Wang, Qin Qi, Yuanyuan Wang, Huangan Wu, Xiaoming Jin, Huan Yao, Duiyin Jin, Yanan Liu and Cun Wang

Cardiac function evaluation for a novel one-step detoxification product of Aconiti Lateralis Radix Praeparata

Aconiti Lateralis Radix Praeparata has been used as the first cardiac drug over a 1000 years in Asian countries. Although most detoxification products are confirmed to be safe, the effect is not potent as desired...

Authors: Ya-nan He, Ding-kun Zhang, Jun-zhi Lin, Xue Han, Ya-ming Zhang, Hai-zhu Zhang, Jin Pei, Ming Yang and Jia-bo Wang

Metabonomic study of the protective effect of Fukeqianjin formula on multi-pathogen induced pelvic inflammatory disease in rats

Fukeqianjin formula has been effectively used in the treatment of pelvic inflammatory disease (PID) and the related complications in clinic. Although there have been some studies about the underlying mechanism...

Authors: Yan Zhang, Wei Li, Liang Zou, Yun Gong, Peng Zhang, Shasha Xing and Hang Yang

Application of metabolomics in toxicity evaluation of traditional Chinese medicines

Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable a...

Authors: Li Duan, Long Guo, Lei Wang, Qiang Yin, Chen-Meng Zhang, Yu-Guang Zheng and E.-Hu Liu

Pharmacological effects of medicinal components of Atractylodes lancea (Thunb.) DC.

Atractylodes lancea Thunb. DC. (AL) has a long history as one of the important herbs used in East Asia. This review is on the purpose of providing a comprehensive summary of the pharmacological effects of AL and ...

Authors: Xie Jun, Peng Fu, Yu Lei and Peng Cheng

Abstracts from the 4th Global Chinese Symposium and the 8th Symposium for cross-straits, Hong Kong and Macao on free radical biology and medicine

Authors:

Abstracts from The International Conference on Medicinal Plants and Bioeconomy & the 1st Sino-CPLP Symposium on Natural Products and Biodiversity Resources

Authors:

Predicting the potential global distribution of diosgenin-contained Dioscorea species

Diosgenin, mainly extracted from wild diosgenin-contained Dioscorea species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological...

Authors: Liang Shen, Jiang Xu, Lu Luo, Haoyu Hu, Xiangxiao Meng, Xiwen Li and Shilin Chen

A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide

Modern studies have shown that adaptogens can non-specifically enhance the resistance of human body under a wide range of external stress conditions with a multi-targeted and multi-channel network-like manner,...

Authors: Lian-ying Liao, Yi-fan He, Li Li, Hong Meng, Yin-mao Dong, Fan Yi and Pei-gen Xiao

Comparing the antidiabetic effects and chemical profiles of raw and fermented Chinese Ge-Gen-Qin-Lian decoction by integrating untargeted metabolomics and targeted analysis

Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years in China. Various beneficial effects of fermentation for applications in TCM or herbals have been rep...

Authors: Yan Yan, Chenhui Du, Zhenyu Li, Min Zhang, Jin Li, Jinping Jia, Aiping Li, Xuemei Qin and Qiang Song

Blood and urinary metabolomic evidence validating traditional Chinese medicine diagnostic classification of major depressive disorder

Major depressive disorder (MDD) is a highly heterogeneous disease. Further classification may characterize its heterogeneity. The purpose of this study was to examine whether metabolomic variables could differ...

Authors: Lan-Ying Liu, Hong-Jian Zhang, Li-Yuan Luo, Jin-Bao Pu, Wei-Qing Liang, Chun-Qin Zhu, Ya-Ping Li, Pei-Rong Wang, Yuan-Yuan Zhang, Chun-Yu Yang and Zhang-Jin Zhang

Indigenous medicinal plants of Pakistan used to treat skin diseases: a review

Plants are providing reliable therapy since time immemorial. Pakistan has a great diversity in medicinal flora and people use these ethno-medicines to deal with many skin problems. This review explores the fun...

Authors: Alamgeer, Amber Sharif, Hira Asif, Waqas Younis, Humayun Riaz, Ishfaq Ali Bukhari and Asaad Mohamed Assiri

The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups

Compounds with the ability to scavenge reactive oxygen species (ROS) and inhibit tyrosinase may be useful for the treatment and prevention from ROS-related diseases. The number and location of phenolic hydroxy...

Authors: Ai-Ren Zuo, Huan-Huan Dong, Yan-Ying Yu, Qing-Long Shu, Li-Xiang Zheng, Xiong-Ying Yu and Shu-Wen Cao

Internationalization of Traditional/Complementary Medicine products: market entry as medicine

Internationalization of Traditional/Complementary Medicine (T&CM) products is important for initiating and sustaining developments in this field. Particularly for traditional Chinese medicines (TCMs), the glob...

Authors: Jiatong Li, Jianfan Zhu, Hao Hu, Joanna E. Harnett, Chi Ieong Lei, Ka Yin Chau, Ging Chan and Carolina Oi Lam Ung

Rapid screening and identification of bioactive compounds specifically binding to beta 2-adrenoceptor from San-ao decoction using affinity magnetic fine particles coupled with high-performance liquid chromatography–mass spectrometry

San-ao decoction (SAD) has been widely used in Chinese medicine against respiratory diseases, such as asthma and rhinallergosis. The bioactive compounds for such pharmacological action remain unknown.

Authors: Fuhuan Fei, Huanmei Sun, Xixi Cheng, Jiajun Liu, Jing Wang, Qian Li and Yajun Zhang

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

Respiratory disorders are a common cause of malady and demise in Pakistan due to its remoteness, cold and harsh climatic conditions as well as scarce health care facilities. The people rely upon the indigenous...

Authors: Alamgeer, Waqas Younis, Hira Asif, Amber Sharif, Humayun Riaz, Ishfaq Ali Bukhari and Asaad Mohamed Assiri

Characterization and anti-tumor activity of a polysaccharide isolated from Dendrobium officinale grown in the Huoshan County

Polysaccharides are carbohydrate chains composed of linked monosaccharide units. Accumulating studies report that polysaccharides isolated from Dendrobium officinale have a variety of functions. However, the comp...

Authors: Yuan Wei, Linwei Wang, Dujun Wang, Dan Wang, Chongwei Wen, Bangxin Han and Zhen Ouyang

A network pharmacology approach to explore the mechanisms of Erxian decoction in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) significantly affects women’s health and well-being. To explore the pharmacological basis of the Erxian decoction (EXD) action in PCOS therapy, a network interaction analysis w...

Authors: Lihong Liu, Bo Du, Haiying Zhang, Xiaofei Guo, Zheng Zhou, Aihui Xiu, Chang Liu, Shiyu Su and Hao Ai

Wnt5a mediates the effects of Bushen Huoxue decoction on the migration of bone marrow mesenchymal stem cells in vitro

Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mese...

Authors: Wei Shen, Hui Luo, Liangliang Xu, Zhifang Wu, Hongtai Chen, Yamei Liu, Lijuan Yu, Liuchao Hu, Bin Wang and Yiwen Luo

Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells

Chemotherapy is a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur with chemotherapy in clinic, resulting in poor prognosis and recurrence. Nowadays, Chinese...

Authors: Zhangfeng Zhong, Haibing Yu, Shengpeng Wang, Yitao Wang and Liao Cui

Application of delayed luminescence method on measuring of the processing of Chinese herbal materials

Based on the principle of tradition Chinese medicine, the processing refers to various techniques that alter the overall properties of herbal materials to meet the requirements of therapeutic applications. How...

Authors: Mengmeng Sun, Wen-Te Chang, Eduard Van Wijk, Min He, Roeland Van Wijk and Mei Wang

Effects of different principles of Traditional Chinese Medicine treatment on TLR7/NF-κB signaling pathway in influenza virus infected mice

Influenza virus is a single-stranded RNA virus that causes influenza in humans and animals. About 600 million people around the world suffer from influenza every year. Upon recognizing viral RNA molecules, TLR...

Authors: Ying-Jie Fu, Yu-Qi Yan, Hong-Qiong Qin, Sha Wu, Shan-Shan Shi, Xiao Zheng, Peng-Cheng Wang, Xiao-Yin Chen, Xiao-Long Tang and Zhen-You Jiang

Diversity and composition of bacterial endophytes among plant parts of Panax notoginseng

Bacterial endophytes are widespread inhabitants inside plant tissues that play crucial roles in plant growth and biotransformation. This study aimed to offer information for the exploitation of endophytes by a...

Authors: Linlin Dong, Ruiyang Cheng, Lina Xiao, Fugang Wei, Guangfei Wei, Jiang Xu, Yong Wang, Xiaotong Guo, Zhongjian Chen and Shilin Chen

Bioaccessibility and risk assessment of heavy metals, and analysis of arsenic speciation in Cordyceps sinensis

Cordyceps sinensis (C. sinensis) is a famous and precious Traditional Chinese Medicine (TCM), while frequent reports of heavy metals, especially arsenic, exceeding standards in C. sinensis in recent years have ra...

Authors: Li Zhou, Sheng Wang, Qingxiu Hao, Liping Kang, Chuanzhi Kang, Jian Yang, Wanzhen Yang, Jingyi Jiang, Lu-Qi Huang and Lanping Guo

Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders

Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurved...

Authors: Aleksandra Tarasiuk, Paula Mosińska and Jakub Fichna

Effect of Da-Cheng-Qi decoction for treatment of acute kidney injury in rats with severe acute pancreatitis

The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including...

Authors: Ling Yuan, Lv Zhu, Yumei Zhang, Huan Chen, Hongxin Kang, Juan Li, Xianlin Zhao, Meihua Wan, Yifan Miao and Wenfu Tang

Siegesbeckia pubescens Makino inhibits Pam₃CSK₄-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation

Siegesbeckia pubescens Makino (SP) is one of the important plant origins for the anti-inflammatory Chinese herbal medicine of Siegesbeckiae Herba. The current investigations indicated that the anti-inflammatory e...

Authors: Wei Sang, Zhangfeng Zhong, Kegang Linghu, Wei Xiong, Anfernee Kai Wing Tse, Wai San Cheang, Hua Yu and Yitao Wang

Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-α and TGF-β

Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressi...

Authors: Chengliang Huang, Xu Wu, Shengpeng Wang, Wenjun Wang, Fang Guo, Yuanyuan Chen, Bi Pan, Ming Zhang and Xianming Fan

Anticancer drug discovery from Chinese medicinal herbs

Cancer is still presenting a serious threat to human health worldwide. The understanding of the complex biology of cancer and the development of oncotherapy have led to increasing treatment approaches such as ...

Authors: Mu-Yang Huang, Le-Le Zhang, Jian Ding and Jin-Jian Lu